How Does Any Vaccine Find the Bad Guys?

Given all the unfortunate hullabaloo about Covid vaccines, I’m reminded of a vague question that has lived at the back of my brain for some time. How does a vaccine get to the places it needs to be to hunt down the small beasts hoping to take us over as their private home? We are filled with harmless invaders who mind their own business in our guts. Some of them even carry their weight by making us healthier. So how does the vaccine get to the ones determined to make us seriously ill?

My curious thoughts: Why not inject into a vein? It would easily travel through our blood circulation system. A needle would more easily pierce fat than muscle, so why not stick us in our pudgy places? I had to dig deep to discover the answers.

If injected into a vein for some reason, a vaccine is vulnerable to destruction. No explanation found.

Muscle unlike fat evidently has a great supply of blood, which helps disperse the vaccine at a measured rate according to  immunology researchers.  Muscle holds and captures dendritic cells that scoop up injected antigens. (An antigen is anything that stimulates an immune response, most commonly dead virus cells or a small amount of living virus cells of the targeted disease.) These cells then migrate to lymph nodes, and take up residence. Our lymph node system is like the body’s built-in vacuum cleaner. The system filters and cleans the lymphatic fluid of any debris, abnormal cells, or pathogens. When the altered dendritic cells encounter white blood cells in the system such as T and B cells—defenders of our bodies from pathogens—they present them with the injected antigen, saying “See this guy? Go get him.”  

I understand the mRNA vaccines work slightly differently. mRNA controls the production of proteins in our body. Many are desirable essential proteins, but not all. For example, Alzheimer’s disease is associated with buildup of particular proteins. Covid cells are coated with a particular and recognizable protein. mRNA vaccines train our cells to go after any guy wearing the signature protein coat, but the vaccines are injected into the muscle and are distributed into the lymph node system in the same way.

With any vaccine, you may have a sore or red arm, slightly enlarged lymph nodes, but this is evidence that the vaccine is working.

I understand Covid nasal spray vaccines are being researched and developed, but I haven’t heard much about them besides the fact that the nose is the entry point for Covid, making the idea seem worth a look.

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